Pharmacyclics, Inc. (Nasdaq: PCYC) presented preclinical results
demonstrating the anti-tumor activity of PCI-27483, the company's
small-molecule Factor VIIa inhibitor. The data were presented during the
Annual Meeting of the American Association for Cancer Research (AACR) being
held this week in San Diego, CA.
Researchers reported that in animal models of human pancreatic tumors,
treatment with PCI-27483 led to inhibition of tumor growth. PCI-27483 was
administered twice daily at either 60 mg/kg or 90 mg/kg, resulting in 42
percent and 85 percent inhibition of tumor growth, respectively, after 15
days of treatment. Additional mechanistic studies showed that PCI-27483
blocked key tumor growth signals. Previous work has shown significant
growth inhibition in lung and colorectal cancer models. Pharmacyclics
anticipates filing an IND for PCI-27483 in the second half of 2008.
"These results support our IND-enabling studies for use of PCI-27483 in
treatment of cancer and to protect against associated thromboembolic
diseases," said David J. Loury, Ph.D., vice president of preclinical
studies for Pharmacyclics. "These findings indicate that Factor VIIa
inhibition is potentially a novel treatment approach for patients whose
tumors depend on Factor VIIa activity for progression."
Factor VII is a blood protein involved in clotting. Many types of
cancer, such as lung, breast, pancreatic, colorectal, gastric and others,
express high levels of a cell surface protein known as tissue factor. After
binding to tissue factor, Factor VII becomes activated and triggers a host
of physiologic processes that facilitate the growth, invasion and spread of
many tumors, as well as angiogenesis, or the growth of new blood vessels
that supply the tumors with nutrients and oxygen. Activation of Factor VII
(Factor VIIa) by tissue factor also leads to the high incidence of
thrombotic complications seen in cancer patients. PCI-27483 selectively
inhibits Factor VIIa when it is complexed with tissue factor.
"We're encouraged by the promising preclinical results with PCI-27483
as we broaden our portfolio of product opportunities," said Richard A.
Miller, M.D., president and chief executive officer of Pharmacyclics. "We
are working to move additional drug candidates forward from our diverse
pipeline, including an HDAC inhibitor, now in a Phase 1 clinical trial for
solid tumors, and motexafin gadolinium, which is currently in two Phase 2
trials sponsored by the National Cancer Institute."
About Pharmacyclics
Pharmacyclics is a pharmaceutical company developing innovative
products to treat cancer and other serious diseases. The company is
leveraging its small-molecule drug development expertise to build a
pipeline in oncology and other diseases based on a wide range of targets,
pathways and mechanisms. More information about the company, its
technology, and products can be found at pharmacyclics.
Pharmacyclics(R) and the "pentadentate" logo(R) are registered trademarks
of Pharmacyclics, Inc.
NOTE: Other than statements of historical fact, the statements made in
this press release about plans for filing an IND for PCI-27483, and other
future plans for our clinical trials, progress of and reports of results
from preclinical and clinical studies, clinical development plans and
product development and corporate partnering activities are forward-looking
statements, as defined in the Private Securities Litigation Reform Act of
1995. The words "project," "believe," "will," "may," "continue," "plan,"
"expect," "intend," "anticipate," variations of such words, and similar
expressions also identify forward-looking statements, but their absence
does not mean that the statement is not forward-looking. The
forward-looking statements are not guarantees of future performance and are
subject to risks and uncertainties that may cause actual results to differ
materially from those in the forward-looking statements. Factors that could
affect actual results include risks associated with unexpected delays in
clinical trials and preclinical studies and the timing for making related
regulatory filings; the fact that data from preclinical studies and Phase 1
or Phase 2 clinical trials may not necessarily be indicative of future
clinical trial results; our ability to estimate accurately the amount of
cash to be used to fund operations over the next 12 months, our ability to
obtain future financing and fund the product development of our pipeline;
the initiation, timing, design, enrollment and cost of clinical trails and
preclinical studies; our ability to establish successful partnerships and
collaborations with third parties; the regulatory approval process in the
United States and other countries; and our future capital requirements. For
further information about these risks and other factors that may affect the
actual results achieved by Pharmacyclics, please see the company's reports
as filed with the U.S. Securities and Exchange Commission from time to
time, including but not limited to its annual report on Form 10-K for the
period ended June 30, 2007 and its subsequently filed quarterly reports on
Form 10-Q. Forward-looking statements contained in this announcement are
made as of this date, and we undertake no obligation to publicly update any
forward-looking statement, whether as a result of new information, future
events or otherwise.
Pharmacyclics, Inc.
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